Sophie Rose is an infectious disease epidemiology fellow at Johns Hopkins Bloomberg School of Public Health. Alongside cofounder Josh Morrison, she established 1Day Sooner, an organization that advocates for human challenge trial volunteers. Her work focuses on systematically evaluating and advocating for the implementation of strategies that will accelerate COVID-19 vaccine development and distribution.

For much of 2020, this involved working alongside stakeholders such as the University of Oxford's Jenner Institute, government working groups and leading experts to ensure COVID-19 human challenge trials could be preserved as an option should a time come when they were approved for use. 1Day Sooner continues to educate the public about challenge trials and their potential impact on the vaccine landscape. They were the recipient of Emergent Ventures anti-COVID-19 prize and have been awarded funding from a number of philanthropic organizations, including The David and Lucile Packard Foundation.

Rose is focusing her career on analyzing global biological risks in the context of public health priority setting and pandemic preparedness in the hope of building a world where pandemics are a thing of the past.