Name: One more reason to get a good night's sleep
Uploaded: 2014-10-13T15:06:31Z
Duration: 11 min 31 s
Description: The brain uses a quarter of the body's entire energy supply, yet only accounts for about two percent of the body's mass. So how does this unique organ receive and, perhaps more importantly, rid itself of vital nutrients? New research suggests it has to do with sleep.

*On Diseases and Symptoms*

Garbage truck of the brain

Appraising the brain's energy budget

Multiplicity of cerebrospinal fluid functions: New challenges in health and disease

Brain-wide pathway for waste clearance captured by contrast-enhanced MRI

A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta

Sleep drives metabolite clearance from the adult brain

Decreased clearance of CNS amyloid-beta in Alzheimer's disease

Alzheimer's disease: The amyloid cascade hypothesis

The amyloid hypothesis for Alzheimer's disease: A critical reappraisal

Self-reported sleep and beta-amyloid deposition in community-dwelling older adults

Sleep quality and preclinical Alzheimer disease

The brain uses a quarter of the body's entire energy supply, yet only accounts for about two percent of the body's mass. So how does this unique organ receive and, perhaps more importantly, rid itself of vital nutrients? New research suggests it has to do with sleep.

Jeff Iliff: One more reason to get a good night's sleep

One more reason to get a good night's sleep

Sleep acts as the brain's housekeeping period, flushing out waste like amyloid-beta, potentially staving off Alzheimer's.

The brain's unique waste clearance system, the glymphatic system, operates primarily during sleep, prioritizing restoration.

Our brains consume a quarter of our body's energy yet harness sleep to efficiently manage waste, highlighting its elegance.