In this season of The TED Interview, conversations with people who make a case for ... optimism. Not some blind, hopeful feeling, but the conviction that somewhere out there are solutions that, given the right attention and resources, can guide us out of the dark place we're in. For the first episode: artificial intelligence. Will innovation in AI drastically improve our lives, or destroy humanity as we know it? Head of TED Chris Anderson sits down with OpenAI CEO Sam Altman, who makes a case for AI's potential to make the future better for all of us -- and explains how his company is leading that charge with an unusual new business model. Listen and subscribe to The TED Interview and more podcasts from the TED Audio Collective wherever you're listening to this.

This past year, scientists racing to stop the novel coronavirus delivered vaccines at a pace and scale the world has never seen before. Adrian Hill, director of Oxford University's vaccine research institute, recounts how he and his team developed the AstraZeneca vaccine. He explains why the challenges were as much about logistics as science, and predicts how the rapid creation of all COVID vaccines could change the pace of medical progress—even in realms beyond vaccines. This episode was recorded on March 8, 2021.

Work as we knew it is undergoing seismic shifts as the pandemic in the U.S. wanes. As some businesses reopen, even people lucky enough to work from home face big questions. What lessons do we take from this past year? How should we lead? How should we talk to each other? How should we even relate to work? Chris turns to Simon Sinek, a thinker and writer on leadership, for some candid guidance in this moment of reinvention.

Before the pandemic struck, young people everywhere abandoned their classrooms and took to the streets. Xiye Bastida was a driving force among these youth climate activists in the U.S. Xiye grew up in Mexico, moved to New York at 13 and started organizing school walk-outs to demand a future unruined by climate change. That movement led to one of the biggest global marches the world has ever seen. In this conversation, Chris and Xiye explore how a group of young people shifted the cultural zeitgeist for a problem that is often seen as too vast, and too entrenched, to overcome.

From the strikes that transformed the world's view on climate change to the marches that demanded equity and justice for Black lives, there has been a new awakening of people passionate about creating change. As founder and CEO of Acumen, Jacqueline Novogratz decided early on to dedicate her life's work to doing just that. In this episode, Chris talks to Jacqueline (who he also happens to be married to) about the wisdom she gained from abandoning a lucrative career as a banker to start a nonprofit dedicated to eradicating global poverty, and the moral imagination -- and difficult tradeoffs -- she believes are necessary to make a transformative impact on the world.

What does it take to persevere and succeed, not just in our careers but in all aspects of our lives? For psychologist Angela Duckworth, the answer can be summed up in one concept: grit. She explains the ingredients in grit and the experiences that make one person persist where another gives up -- and offers concrete steps to instill grit early in life and sustain it. Listen and subscribe to The TED Interview and more podcasts from the TED Audio Collective at audiocollective.ted.com.

Some believe our world has changed at a rapid pace in recent decades. From the rise of the internet to the proliferation of startups spinning out inventions, it can certainly seem that way. In this episode, though, economist Tyler Cowen argues that none of this has really transformed the ways we live over the last 50 years. But he contends that now that's changing, as new breakthroughs in science and medicine push us out of the so-called ""Great Stagnation"" into a new era of meaningful innovation.

Biochemist Jennifer Doudna won the 2020 Nobel Prize in Chemistry for pioneering CRISPR, a revolutionary biotech tool that can edit DNA with unprecedented precision and ease. But how exactly does CRISPR work, and what consequences may arise from altering our internal makeup? She talks to Chris about the remarkable effects CRISPR can have on our lives--from eradicating genetic diseases to slowing the climate crisis--as well as the ethical and moral questions we must grapple with when it comes to changing who we are.

The coronavirus pandemic shattered the global economy. To put the pieces back together, we need to make sure money is going to the countries that need it the most -- and that we rebuild financial systems that are resilient to shocks, says Kristalina Georgieva, managing director of the International Monetary Fund. She takes us inside the massive economic stimulus efforts leading the world toward recovery and renewal and discusses what it will take for countries to emerge from this "great transformation" even stronger than before. (This virtual conversation, hosted by head of TED Chris Anderson and current affairs curator Whitney Pennington Rodgers, was recorded on May 18, 2020.)

In a time of mourning and anger over the ongoing violence inflicted on Black communities by police in the US and the lack of accountability from national leadership, what is the path forward? Sharing urgent insights into this historic moment, Dr. Phillip Atiba Solomon, Rashad Robinson, Dr. Bernice King and Anthony D. Romero discuss dismantling the systems of oppression and racism responsible for tragedies like the murders of Ahmaud Arbery, Breonna Taylor, George Floyd and far too many others -- and explore how the US can start to live up to its ideals. (This discussion, hosted by head of TED Chris Anderson and current affairs curator Whitney Pennington Rodgers, was recorded on June 3, 2020.)

Can technology create a democracy that's fast, fair ... and even fun? Digital minister Audrey Tang shares how Taiwan avoided a COVID-19 shutdown in early 2020 through innovations like developing apps to map mask availability, crowdsourcing ideas that could become laws and creating a "humor over rumor" campaign to combat disinformation with comedy. (This virtual conversation, hosted by TED science curator David Biello and current affairs curator Whitney Pennington Rodgers, was recorded June 1, 2020.)

Capitalism needs an upgrade, says PayPal CEO Dan Schulman, and it starts with paying people enough to actually invest in their futures. He discusses why companies need to cultivate trust to recover and rebuild after the COVID-19 pandemic -- and how we can use this defining moment to create a more inclusive, ethical economy. (This virtual conversation, hosted by TED business curator Corey Hajim and current affairs curator Whitney Pennington Rodgers, was recorded on May 19, 2020.)

Ashraf Ghani shares his thoughts on peacemaking, the true cost of war, the nation's COVID-19 response strategy and the sweeping economic and social reforms happening throughout the country. (This virtual conversation, hosted by head of TED Chris Anderson, was recorded June 16, 2020.)

The coronavirus brought much of the world to a standstill, dropping carbon emissions by five percent. Al Gore says keeping those rates down is now up to us. In this illuminating interview, he discusses how the steadily declining cost of wind and solar energy will transform manufacturing, transportation and agriculture, offer a cheaper alternative to fossil fuels and nuclear energy and create millions of new jobs. Stay tuned for a lively debate about geoengineering and hear Gore's thoughts about how humanity can create a clean, prosperous future through a focused global effort and a generation of young people committed to change. (This virtual conversation, hosted by head of TED Chris Anderson, was recorded June 23, 2020.)

If we want to build back better after the pandemic, we must reconsider philanthropy and create a new kind of capitalism that's rooted in generosity and accountability, says Darren Walker, president of the Ford Foundation. In this vital conversation, Walker calls for citizens and corporations to question the inequality that makes their wealth possible, to think about their own complicity in creating economic injustice and to celebrate the critical role art plays in creating a culture that uplifts everyone. (This virtual conversation, hosted by head of TED Chris Anderson, was recorded July 1, 2020.)

Education activist (and recent Oxford graduate) Malala Yousafzai reflects on the defining moments of her life, how she balances passion with personhood and where the world finds itself during the COVID-19 crisis. With humor and humility, she shares her dreams of seeing social progress in her lifetime, explains why girls education advocacy must not relent during the pandemic and champions youth activists worldwide leading the fight for a fairer future for all. (This virtual conversation, hosted by TED's current affairs curator Whitney Pennington Rodgers, was recorded July 8, 2020.)

"Life's beauty is inseparable from its fragility," says psychologist Susan David. In a special virtual conversation, she shares wisdom on how to build resilience, courage and joy in the midst of the coronavirus pandemic. Responding to listeners' questions from across the globe, she offers ways to talk to your children about their emotions, keep focus during the crisis and help those working on the front lines. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and current affairs curator Whitney Pennington Rodgers. Recorded March 23, 2020)

Philanthropist and Microsoft cofounder Bill Gates offers insights into the COVID-19 pandemic, discussing why testing and self-isolation are essential, which medical advancements show promise and what it will take for the world to endure this crisis. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and current affairs curator Whitney Pennington Rodgers. Recorded March 24, 2020)

When will the coronavirus vaccine be ready? Epidemiologist Seth Berkley (head of Gavi, the Vaccine Alliance) takes us inside the effort to create a vaccine for COVID-19. With clarity and urgency, he explains what makes it so challenging to develop, when we can expect it to be rolled out at scale and why we'll need global collaboration to get it done. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and current affairs curator Whitney Pennington Rodgers. Recorded March 26, 2020)

From Hong Kong, South China Morning Post CEO Gary Liu tracks China's response to the coronavirus pandemic -- from the initial outbreak in Wuhan to the shutdown of Hubei province and the containment measures taken across its major cities. Sharing insights into how the culture in places like Hong Kong and South Korea contributed to fast action against the virus, Liu identifies lessons people across the world can use to stop its spread. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and current affairs curator Whitney Pennington Rodgers. Recorded March 25, 2020)

Author Priya Parker shares tools for creating meaningful connections with friends, family and coworkers during the coronavirus pandemic -- and shows how we can take advantage of gatherings that are unique to this moment of social distancing. "We don't necessarily need to gather more," she says. "We need to gather better." (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and current affairs curator Whitney Pennington Rodgers. Recorded March 27, 2020)

Rabbi Lord Jonathan Sacks offers thoughts on how we can navigate the coronavirus pandemic with courage, hope and empathy. With wisdom and clarity, he speaks on leadership, fear, death, hope and how we could use this moment to build a more just world. Watch for a special, impromptu prayer about halfway through the conversation. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and head of curation Helen Walters. Recorded March 30, 2020)

What can past pandemics teach us how to tackle the current one? Tracing the history of contagions from cholera to Ebola and beyond, science journalist Sonia Shah explains why we're more vulnerable to outbreaks now than ever before, what we can do to minimize the spread of coronavirus and how to prevent future pandemics. (This virtual conversation is part of the TED Connects series, hosted by science curator David Biello and current affairs curator Whitney Pennington Rodgers. Recorded March 31, 2020)

A good night's sleep has perhaps never been more important. Sharing wisdom and debunking myths, sleep scientist Matt Walker discusses the impact of sleep on mind and body -- from unleashing your creative powers to boosting your memory and immune health -- and details practices you can start (and stop) doing tonight to get some rest. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and current affairs curator Whitney Pennington Rodgers. Recorded April 1, 2020)

If you're feeling anxious or fearful during the coronavirus pandemic, you're not alone. Offering hope and understanding, author Elizabeth Gilbert reflects on how to stay present, accept grief when it comes and trust in the strength of the human spirit. "Resilience is our shared genetic inheritance," she says. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and head of curation Helen Walters. Recorded April 2, 2020)

As COVID-19 continues to spread, the world is facing two existential threats at once: a public health emergency and an economic crisis. Political theorist Danielle Allen describes how we can ethically and democratically address both problems by scaling up "smart testing," which would track positive cases with peer-to-peer software on people's cell phones -- so we can end the pandemic and get back to work. (This virtual conversation is part of the TED Connects series, hosted by head of TED Chris Anderson and business curator Corey Hajim. Recorded April 6, 2020)

The coronavirus pandemic is unlike anything we've ever seen in health care, says emergency physician Esther Choo. Sharing insights into how health workers are responding to the outbreak, she explains what makes this public health emergency different from others -- and provides a few simple things you can do to help. Watch to the end to hear about Choo's work deploying mobile ICUs across the United States as hospitals start to reach capacity. (This virtual conversation is part of the TED Connects series, hosted by current affairs curator Whitney Pennington Rodgers and head of curation Helen Walters. Recorded April 7, 2020)

Looking to put your skills to use to fight the pandemic? Consider joining The Global Hack, a virtual hackathon designed to rapidly develop solutions to the coronavirus crisis. Designer and technologist Marko Russiver shares the motivation behind a movement looking to help people build post-pandemic resilience. (This virtual conversation is part of the TED Connects series, hosted by head of curation Helen Walters. Recorded April 8, 2020)

Psychologist Daniel Gilbert delves deep into the weird, counterintuitive science of happiness -- and explains why our minds worry about things we needn't worry about (and fail to worry about things we really should worry about). (Audio only)

Is the dress blue or gold? Do you hear "laurel" or "yanny"? Neuroscientist Anil Seth digs into why we all perceive the world so differently, and tries to explain the biggest mystery of all: consciousness. (Audio only)

Best-selling author Elif Shafak proves that storytelling can be profoundly political -- and makes the case for embracing uncertainty in turbulent times. (Audio only)

At 26, Michael Tubbs ran for Mayor of Stockton, California, hoping to transform a city in crisis into a community of opportunity. He won. Mayor Tubbs breaks down how initiatives like universal basic income can free people from poverty, what being a good neighbor means in a democratic society, and why eradicating cycles of crime requires helping victims AND perpetrators. (Audio only)

Endless growth may actually be hurting our economy -- and our planet. Economist Kate Raworth makes a case for "doughnut economics": an alternative way to look at the economic systems ruling our societies and imagine a sustainable future for all. (Audio only)

According to cognitive scientist Donald Hoffman, our brains are showing us a "hacked" version of reality. His revolutionary new way of thinking about consciousness combines the study of evolution with insights into brain activity in an attempt to solve the mysteries behind how we perceive the world. (Audio only)

A professor at Harvard Business School and expert in work culture, Frei goes into companies like WeWork and Uber with the goal of turning toxic environments into healthy, inclusive spaces. She shares why authenticity, logic and empathy are the most vital skills an employee can have -- and how the measure of a true leader can be seen not just in their presence, but in their absence, too. (Audio Only)

In 2015, Christiana Figueres brokered the historic Paris Agreement to combat climate change. She gives an inside look at the negotiations that led to a commitment from 195 countries to work toward a low carbon future and discusses her current work on COUNTDOWN, an ambitious new initiative from TED aiming to reduce greenhouse gas emissions to net zero. (Audio only)

Microsoft founder Bill Gates takes us deep into his remarkable history and propels us into the future of technology and philanthropy. (Audio only)

An intimate conversation with one of the most unique voices in music today. Amanda Palmer shows us how the future of creative work means asking for what you want. (Audio only)

New York Times pundit David Brooks describes a plan to rebuild broken communities and offers actionable steps to live a more meaningful life. (Audio only)

Technologist Kai-Fu Lee describes the high-stakes battle between the West and China in artificial intelligence, and what it means for the future of work. (Audio only)

Self-confessed introvert Susan Cain delves deep into this complex personality trait, offering ideas for better offices, better schools and better relationships. (Audio only)

Is the future of our economy scary? Exciting? MIT research scientist Andrew McAfee argues that it's both. (Audio only)

Dive deep into the fascinating, horrifying, hopeful story of the ocean with world-renowned marine biologist Sylvia Earle. (Audio only)

Monica Lewinsky reveals the very personal price to public humiliation and explores how we can all do better. (Audio only)

Life-hack master Tim Ferriss gives an intimate look into the darker moments in his life, his Stoic philosophy, and his new passion for psychedelics. (Audio only)

Historian and futurist Yuval Noah Harari has a story about the future that's profound, exciting and unsettling. (Audio only)

Author Johann Hari offers a deeply personal and surprisingly uplifting perspective on how to tackle depression. (Audio only)

As a writer, Elizabeth Gilbert is notorious for placing her heart squarely on her sleeve. Her best-selling memoir "Eat Pray Love" was a sensation precisely because of her eloquent, open-hearted descriptions of fear, divorce and wanting everything life had to offer. When she spoke at TED back in 2009, she charmed the audience with her frank descriptions of what happened after the book became a runaway success and her lyrical ideas of the nature of creativity. Nearly ten years later, in this extraordinarily intimate conversation with TED curator Chris Anderson, she shares why openness, transparency and creativity are still central to her philosophy of life -- even when faced with moments of desperation and personal tragedy.

It can be easy to believe that humans are insignificant. We're specks of dust on a random planet in a vast universe. Less powerful than elephants. Fewer than ants. But David Deutsch believes that's all beside the point, because humans possess one unique skill: attaining knowledge. David Deutsch -- Oxford professor, father of quantum computing, recluse -- convinced Chris Anderson years ago to take over leadership of TED with his ideas about knowledge. In this mind-bending conversation, the two dive into his theory that the potential reach of knowledge is infinite. They explore how knowledge first developed, why it sets us apart and what all of these heady concepts really mean for our present and future.

Many philosophers draw a hard line between the worlds of facts and values, but not Sam Harris. In this thought-provoking conversation with Chris Anderson, he makes the case that reason can indeed answer moral questions, and then explores the many controversies that emerge from that claim. Moral superiority? Cultural superiority? How about moral progress? Chris and Sam dig in to discuss the right ways to think about defining right from wrong, and reason's role in it all.

Just after 9/11, Dalia Mogahed asked: What do 1.8 billion Muslims really think? In a grand research project with Gallup, she interviewed more than 50,000 Muslims about their lives, their dreams and the state of their religion. Today, she continues her research on Muslims as the director of research at the Institute for Social Policy and Understanding. In this intimate conversation with head of TED Chris Anderson, she opens up about her own faith and shares what she believes are the most common misconceptions of the world's second-biggest religion.

Was 2017 really the "the worst ever," as some would have us believe? Cognitive psychologist and linguist Steven Pinker shares data that shows: actually, it was one of the best overall. At TED2018, head of TED Chris Anderson sat down with Steven to take a closer look at the data that suggest the world is improving -- and to unpack why so many people find this idea so challenging.

On any given night, 450,000 people in the United States stay in jail without having been convicted of any crime. Most of them are there because they don't have enough money to pay bail. Exasperated at what she saw as a systemic design flaw that primarily affects poor and marginalized people, public defense lawyer Robin Steinberg came up with a plan to fix things. As she explains in this sparky conversation with head of TED Chris Anderson, that idea is about as bold as they get.

Talking about race can be difficult. But Mellody Hobson argues that we need to do it anyway -- boldly and often. Mellody is the president of Ariel Investments, a firm that manages more than 13 billion dollars. And throughout her career and in her personal life, she's experienced just how corrosive it can be when people choose to be "color blind." In this candid conversation, she shares her vision of a more harmonious, diverse America -- and the difficult truths we need to swallow (and discuss) to get there.

Join head of TED Chris Anderson for a very special conversation with legendary inventor and computer scientist Ray Kurzweil, recorded live onstage at TED2018. Listen in to hear what the man who makes a living from predicting the future arc of technology thinks is coming our way next -- including a specific prediction of when he thinks technology will finally gain human levels of language understanding.

\What shapes happiness -- the experiences we have, or the stories we tell ourselves about them afterwards? When and how does our intuition reliably fail? And why is overconfidence the fatal flaw we should all watch out for? In this fascinating, far-ranging conversation, head of TED Chris Anderson digs into the questions that really matter with Danny Kahneman -- Nobel laureate, godfather of behavioral economics and one of the most influential psychologists alive.

Do schools kill creativity? Back in 2006, Sir Ken Robinson posed this question to the TED audience -- and boy, did it touch a nerve. More than fifty million views and a decade later, head of TED Chris Anderson sits down with Sir Ken to dig into the changes and progress that have been made, and to see if the answer now is any different. How are educators thinking about creativity these days? And why should creativity be a focus at all? With his characteristic verve, wit and sparkle, Sir Ken explains all. (Audio only)