What doctors worry about

If you take two different medications for two different reasons, here's a sobering thought: your doctor may not fully understand what happens when they're combined, because drug interactions are incredibly hard to study. In this fascinating and accessible talk, Russ Altman shows how doctors are studying unexpected drug interactions using a surprising resource: search engine queries.

Every doctor makes mistakes. But, says physician Brian Goldman, medicine's culture of denial (and shame) keeps doctors from ever talking about those mistakes, or using them to learn and improve. Telling stories from his own long practice, he calls on doctors to start talking about being wrong.

You might not know this: Many of the medicines we take -- common drugs like Ambien and everyday aspirin -- were only ever tested on men. And the unknown side effects for women can be dangerous, even deadly. Alyson McGregor studies the differences between male and female patients; in this fascinating talk she explains how the male model became our framework for medical research ... and what women and men need to ask their doctors to get the right care for their bodies.

Modern medicine is in danger of losing a powerful, old-fashioned tool: human touch. Physician and writer Abraham Verghese describes our strange new world where patients are merely data points, and calls for a return to the traditional one-on-one physical exam.

Surprising, but true: More women now die of heart disease than men, yet cardiovascular research has long focused on men. Pioneering doctor C. Noel Bairey Merz shares what we know and don't know about women's heart health -- including the remarkably different symptoms women present during a heart attack (and why they're often missed).

Dr. Ernest Madu runs the Heart Institute of the Caribbean in Kingston, Jamaica, where he proves that -- with careful design, smart technical choices, and a true desire to serve -- it's possible to offer world-class healthcare in the developing world.

Every cell in the human body has a sex, which means that men and women are different right down to the cellular level. Yet too often, research and medicine ignore this insight -- and the often startlingly different ways in which the two sexes respond to disease or treatment. As pioneering doctor Paula Johnson describes in this thought-provoking talk, lumping everyone in together means we essentially leave women's health to chance. It's time to rethink.

We can't control if we'll die, but we can "occupy death," in the words of Peter Saul, an emergency doctor. He asks us to think about the end of our lives -- and to question the modern model of slow, intubated death in hospital. Two big questions can help you start this tough conversation.