Keolu Fox Why genetic research must be more diverse
Ninety-six percent of genome studies are based on people of European descent. The rest of the world is virtually unrepresented — and this is dangerous, says geneticist and TED Fellow Keolu Fox, because we react to drugs differently based on our genetic makeup. Fox is working to democratize genome sequencing, specifically by advocating for indigenous populations to get involved in research, with the goal of eliminating health disparities. "The research community needs to immerse itself in indigenous culture," he says, "or die trying."
Paul Knoepfler The ethical dilemma of designer babies
Creating genetically modified people is no longer a science fiction fantasy; it's a likely future scenario. Biologist Paul Knoepfler estimates that within fifteen years, scientists could use the gene editing technology CRISPR to make certain "upgrades" to human embryos — from altering physical appearances to eliminating the risk of auto-immune diseases. In this thought-provoking talk, Knoepfler readies us for the coming designer baby revolution and its very personal, and unforeseeable, consequences.
Stephen Friend The hunt for "unexpected genetic heroes"
What can we learn from people with the genetics to get sick — who don't? With most inherited diseases, only some family members will develop the disease, while others who carry the same genetic risks dodge it. Stephen Friend suggests we start studying those family members who stay healthy. Hear about the Resilience Project, a massive effort to collect genetic materials that may help decode inherited disorders.
Richard Resnick Welcome to the genomic revolution
Cheap and fast genome sequencing is about to turn health care (and insurance, and politics) upside down. Richard Resnick shows how, in this accessible talk.
Jennifer Kahn Gene editing can now change an entire species — forever
CRISPR gene drives allow scientists to change sequences of DNA and guarantee that the resulting edited genetic trait is inherited by future generations, opening up the possibility of altering entire species forever. More than anything, the technology has led to questions: How will this new power affect humanity? What are we going to use it to change? Are we gods now? Join journalist Jennifer Kahn as she ponders these questions and shares a potentially powerful application of gene drives: the development of disease-resistant mosquitoes that could knock out malaria and Zika.
Juan Enriquez What will humans look like in 100 years?
We can evolve bacteria, plants and animals — futurist Juan Enriquez asks: Is it ethical to evolve the human body? In a visionary talk that ranges from medieval prosthetics to present day neuroengineering and genetics, Enriquez sorts out the ethics associated with evolving humans and imagines the ways we'll have to transform our own bodies if we hope to explore and live in places other than Earth.