Each year, hundreds of thousands of people around the world die of malaria. Aided by a demo from Freya the malaria-sniffing dog, infectious disease researcher James Logan describes the role of scent in the spread of malaria and explains how dogs can help break that cycle.

Bill Gates hopes to solve some of the world's biggest problems using a new kind of philanthropy. In a passionate and, yes, funny 18 minutes, he asks us to consider two big questions and how we might answer them. (And see the Q&A on the TED Blog.)

The malaria vaccine was invented more than a century ago -- yet each year, hundreds of thousands of people still die from the disease. How can we improve this vital vaccine? In this informative talk, immunologist and TED Fellow Faith Osier shows how she's combining cutting-edge technology with century-old insights in the hopes of creating a new ...

We’ve known how to cure malaria since the 1600s, so why does the disease still kill hundreds of thousands every year? It’s more than just a problem of medicine, says journalist Sonia Shah. A look into the history of malaria reveals three big-picture challenges to its eradication. Photos: Adam Nadel.

Nathan Myhrvold and team's latest inventions -- as brilliant as they are bold -- remind us that the world needs wild creativity to tackle big problems like malaria. And just as that idea sinks in, he rolls out a live demo of a new, mosquito-zapping gizmo you have to see to believe.

What if we could diagnose some of the world's deadliest diseases by the smells our bodies give off? In a fascinating talk and live demo, biologist James Logan introduces Freya, a malaria-sniffing dog, to show how we can harness the awesome powers of animal scent to detect chemical signatures associated with infection -- and change the way we dia...

Admit it, lasers are pretty cool. Discover the awesome, ingenious ways these beams of light are being used to fight against malaria and HIV, scan ancient monuments ... and even edit memory.

Seth Berkley explains how smart advances in vaccine design, production and distribution are bringing us closer than ever to eliminating a host of global threats -- from AIDS to malaria to flu pandemics.

Everyone hates mosquitos. Besides the annoying buzzing and biting, mosquito-borne diseases like malaria kill over a million people each year (plus horses, dogs and cats). And over the past 100 million years, they've gotten good at their job -- sucking up to three times their weight in blood, totally undetected. So shouldn't we just get rid of th...

Biochemist Joe DeRisi talks about amazing new ways to diagnose viruses (and treat the illnesses they cause) using DNA. His work may help us understand malaria, SARS, avian flu -- and the 60 percent of everyday viral infections that go undiagnosed.

We can use a mosquito's own instincts against her. In a rather unforgettable presentation, Bart Knols demos the imaginative solutions his team is developing to fight malaria -- including Limburger cheese and a deadly pill.

Wendy Woods reveals the powerful impact of collective cooperation in the social sector. Using examples of different NGOs, each one working independently to eradicate malaria, she explains how an individualistic approach reduced their efforts and resulted in fatal inefficiencies -- and what happened when they finally aligned their overall mission.

Alisa Miller, head of Public Radio International, talks about why -- though we want to know more about the world than ever -- the media is actually showing us less. Eye-opening stats and graphs.

In a single year, there are 200-300 million cases of malaria and 50-100 million cases of dengue fever worldwide. So: Why haven't we found a way to effectively kill mosquitos yet? Hadyn Parry presents a fascinating solution: genetically engineering male mosquitos to make them sterile, and releasing the insects into the wild, to cut down on diseas...

Paul Moller talks about the future of personal air travel -- the marriage of autos and flight that will give us true freedom to travel off-road. He shows two things he's working on: the Moller Skycar (a jet + car) and a passenger-friendly hovering disc.

Your company might have donated money to help solve humanitarian issues, but you could have something even more useful to offer: your data. Mallory Freeman shows us how private sector companies can help make real progress on big problems -- from the refugee crisis to world hunger -- by donating untapped data and decision scientists. What might y...

At the end of our lives, what do we most wish for? For many, it's simply comfort, respect, love. BJ Miller is a hospice and palliative medicine physician who thinks deeply about how to create a dignified, graceful end of life for his patients. Take the time to savor this moving talk, which asks big questions about how we think on death and honor...

Dissenters are often dismissed as disruptive, disrespectful and annoying. But when it comes to business, challenging the status quo can bring much needed change to any organization. Andrew Millar defends the dissenters of the world, arguing that these stalwarts are arguing out of compassion with an aim to improve ideas. In this impassioned talk,...

In 2008, two 9,000-year old skeletons were found with their bones infected by an all too familiar bacterium. The ancient Greeks knew its effects as phthisis; the Incans called it chaky oncay; and today we call it tuberculosis, or TB. TB is still one of the world's most infectious killers, causing more deaths than malaria or even HIV. How has it ...

In 2008, something incredible happened: a man was cured of HIV. In over 70 million HIV cases, this was a first, and, so far, a last, and we don't yet understand exactly how he was cured. But if we can cure people of various diseases, like malaria and hepatitis C, why can't we cure HIV? Janet Iwasa examines the specific traits of the HIV virus th...

At the Center for Disease Dynamics, Economics & Policy, economist Ramanan Laxminarayan looks at big-picture issues of global health.

Inspired by the repetition in our daily work lives, BCG Global Creative Director Frank Müller-Pierstorff created an electronic sound installation that combines musical and video loops to embody -- and ultimately break through --the "cages" of our routines.

Fredros Okumu studies human-mosquito interactions, hoping to better understand how to keep people from getting malaria.

"We are living in a world that is tantalizingly close to ensuring that no one need die of hunger or malaria or diarrhea," says economist Michael Green. To help spur progress, back in 2015 the United Nations drew up a set of 17 goals around important factors like health, education and equality. In this data-packed talk, Green shares his analysis ...

In 2002, the Colombian guerrilla movement known as the FARC (Revolutionary Armed Forces of Colombia) kidnapped Ingrid Betancourt in the middle of her presidential campaign. For the next six years, Betancourt was held hostage in jungle prison camps where she was ravaged by malaria, fleas, hunger and human cruelty until her rescue by the Colombian...

CRISPR gene drives allow scientists to change sequences of DNA and guarantee that the resulting edited genetic trait is inherited by future generations, opening up the possibility of altering entire species forever. More than anything, the technology has led to questions: How will this new power affect humanity? What are we going to use it to ch...

Faith Osier is studying how humans acquire immunity to malaria and developing new malaria vaccines.

When we asked Bill Gates to curate a list of his favorite talks, his first response was, “There are too many to pick, really.” Here, he's whittled it down to 13 essentials.

Loki the mischief-maker, writhes in Thor's iron grip. The previous night, he'd snuck up on Thor's wife and shorn off her beautiful hair. To fix what he'd done, Loki rushes to the dwarves and tricks them into making gifts for the gods. Wanting to best their smith rivals, the dwarves make a set of golden treasures, including a hammer called Mjolni...

For the nearly 20 million Americans with a felony record, punishment doesn't end after their prison sentence. Sociologist Reuben Jonathan Miller sheds light on the aftershocks of mass incarceration through the stories of people who've lived it, left it and still have to grapple with punishing policies after their release. A challenge to rethink ...