Nobel laureate James Watson opens TED2005 with the frank and funny story of how he and his research partner, Francis Crick, discovered the structure of DNA.

Many people think the lines on the map no longer matter, but Parag Khanna says they do. Using maps of the past and present, he explains the root causes of border conflicts worldwide and proposes simple yet cunning solutions for each.

Environmental scientist David Keith proposes a cheap, effective, shocking means to address climate change: What if we injected a huge cloud of ash into the atmosphere to deflect sunlight and heat?

For the dawn of a new decade, adventurer Bertrand Piccard offers us a challenge: Find motivation in what seems impossible. He shares his own plans to do what many say can't be done -- to fly around the world, day and night, in a solar-powered aircraft.

Backed by stunning illustrations, David Christian narrates a complete history of the universe, from the Big Bang to the Internet, in a riveting 18 minutes. This is "Big History": an enlightening, wide-angle look at complexity, life and humanity, set against our slim share of the cosmic timeline.

"Is it okay if I totally trash your office?" It's a question Elyn Saks once asked her doctor, and it wasn't a joke. A legal scholar, in 2007 Saks came forward with her own story of schizophrenia, controlled by drugs and therapy but ever-present. In this powerful talk, she asks us to see people with mental illness clearly, honestly and compassion...

Most of us want to do the right thing when it comes to the environment. But things aren’t as simple as opting for the paper bag, says sustainability strategist Leyla Acaroglu. A bold call for us to let go of tightly-held green myths and think bigger in order to create systems and products that ease strain on the planet.

Babble.com publishers Rufus Griscom and Alisa Volkman, in a lively tag-team, expose 4 facts that parents never, ever admit -- and why they should. Funny and honest, for parents and nonparents alike.

India is fast becoming a superpower, says Shashi Tharoor -- not just through trade and politics, but through "soft" power, its ability to share its culture with the world through food, music, technology, Bollywood. He argues that in the long run it's not the size of the army that matters as much as a country's ability to influence the world's he...

How do we search for alien life if it's nothing like the life that we know? Christoph Adami shows how he uses his research into artificial life -- self-replicating computer programs -- to find a signature, a "biomarker," that is free of our preconceptions of what life is.

Adam Savage talks about his fascination with the dodo bird, and how it led him on a strange and surprising double quest. It's an entertaining adventure through the mind of a creative obsessive.

Chris Domas is a cybersecurity researcher, operating on what's become a new front of war, "cyber." In this engaging talk, he shows how researchers use pattern recognition and reverse engineering (and pull a few all-nighters) to understand a chunk of binary code whose purpose and contents they don't know.

Cosmologist Sean Carroll attacks -- in an entertaining and thought-provoking tour through the nature of time and the universe -- a deceptively simple question: Why does time exist at all? The potential answers point to a surprising view of the nature of the universe, and our place in it.

So the Mars Rovers didn't scoop up any alien lifeforms. Scientist Penelope Boston thinks there's a good chance -- a 25 to 50 percent chance, in fact -- that life might exist on Mars, deep inside the planet's caves. She details how we should look and why.

"If I should have a daughter, instead of Mom, she's gonna call me Point B ... " began spoken word poet Sarah Kay, in a talk that inspired two standing ovations at TED2011. She tells the story of her metamorphosis -- from a wide-eyed teenager soaking in verse at New York's Bowery Poetry Club to a teacher connecting kids with the power of self-exp...

Scientific discoveries, futurist Juan Enriquez notes, demand a shift in code, and our ability to thrive depends on our mastery of that code. Here, he applies this notion to the field of genomics.

When will the coronavirus vaccine be ready? Epidemiologist Seth Berkley (head of Gavi, the Vaccine Alliance) takes us inside the effort to create a vaccine for COVID-19. With clarity and urgency, he explains what makes it so challenging to develop, when we can expect it to be rolled out at scale and why we'll need global collaboration to get it ...

After 15 years in the British diplomatic corps, Carne Ross became a "freelance diplomat," running a bold nonprofit that gives small, developing and yet-unrecognized nations a voice in international relations. At the BIF-5 conference, he calls for a new kind of diplomacy that gives voice to small countries, that works with changing boundaries and...

Mae Jemison is an astronaut, a doctor, an art collector, a dancer ... Telling stories from her own education and from her time in space, she calls on educators to teach both the arts and sciences, both intuition and logic, as one -- to create bold thinkers.

Our leaders need to be held accountable, says journalist Heather Brooke. And she should know: Brooke uncovered the British Parliamentary financial expenses that led to a major political scandal in 2009. She urges us to ask our leaders questions through platforms like Freedom of Information requests -- and to finally get some answers.

MIT professor Neil Gershenfeld talks about his Fab Lab -- a low-cost lab that lets people build things they need using digital and analog tools. It's a simple idea with powerful results.

Ocean explorer Robert Ballard takes us on a mindbending trip to hidden worlds underwater, where he and other researchers are finding unexpected life, resources, even new mountains. He makes a case for serious exploration and mapping. Google Ocean, anyone?

Technologist and futurist Bill Joy talks about several big worries for humanity -- and several big hopes in the fields of health, education and future tech.

People often credit their ideas to individual "Eureka!" moments. But Steven Johnson shows how history tells a different story. His fascinating tour takes us from the "liquid networks" of London's coffee houses to Charles Darwin's long, slow hunch to today's high-velocity web.

Inventor, entrepreneur and visionary Ray Kurzweil explains in abundant, grounded detail why, by the 2020s, we will have reverse-engineered the human brain and nanobots will be operating your consciousness.

Here's a crazy idea: Persuade the world to try living in peace for just one day, every September 21. In this energetic, honest talk, Jeremy Gilley tells the story of how this crazy idea became real -- real enough to help millions of kids in war-torn regions.

Accepting his 2005 TED Prize, photographer Edward Burtynsky makes a wish: that his images -- stunning landscapes that document humanity's impact on the world -- help persuade millions to join a global conversation on sustainability.

Just over 27 years ago, Claude Nicollier boarded the Space Shuttle Atlantis to become the first Swiss man to travel into space. This historical event marked the commencement of Nicollier’s unbelievable journey; both in outer space and on earth. The astronaut and astrophysicist has participated in a total of four space shuttle missions, two of th...