Why do girls feel empowered to engage in sexual activity but not to enjoy it? For three years, author Peggy Orenstein interviewed girls ages 15 to 20 about their attitudes toward and experiences of sex. She discusses the pleasure that's largely missing from their sexual encounters and calls on us to close the "orgasm gap" by talking candidly wit...

To honor and celebrate young lives cut short, Kathy Hull founded the first freestanding pediatric palliative care facility in the United States, the George Mark Children's House. Its mission: to give terminally ill children and their families a peaceful place to say goodbye. She shares stories brimming with wisdom, joy, imagination and heartbrea...

Sue Klebold is the mother of Dylan Klebold, one of the two shooters who committed the Columbine High School massacre, murdering 12 students and a teacher. She's spent years excavating every detail of her family life, trying to understand what she could have done to prevent her son's violence. In this difficult, jarring talk, Klebold explores the...

In her brutally honest, ironically funny and widely read meditation on death, "You May Want to Marry My Husband," the late author and filmmaker Amy Krouse Rosenthal gave her husband Jason very public permission to move on and find happiness. A year after her death, Jason offers candid insights on the often excruciating process of moving through ...

Meet Sharon Terry, a former college chaplain and stay-at-home mom who took the medical research world by storm when her two young children were diagnosed with a rare disease known as pseudoxanthoma elasticum (PXE). In this knockout talk, Terry explains how she and her husband became citizen scientists, working midnight shifts at the lab to find ...

We need to talk to kids about the risks they face online, says information security expert Sebastián Bortnik. In this talk, Bortnik discusses the issue of "grooming" -- the sexual predation of children by adults on the internet -- and outlines the conversations we need to start having about technology to keep our kids safe. (In Spanish with Engl...

Racism is making people sick -- especially black women and babies, says Miriam Zoila Pérez. The doula turned journalist explores the relationship between race, class and illness and tells us about a radically compassionate prenatal care program that can buffer pregnant women from the stress that people of color face every day.

Twenty-three Grand Slam titles later, tennis superstar Serena Williams sits down with journalist Gayle King to share a warm, mischievous conversation about her life, love, wins and losses -- starting with the story of how she accidentally shared her pregnancy news with the world.

It doesn't matter whether you love or hate guns; it's obvious that the US would be a safer place if there weren't thousands of them sold every day without background checks. Dan Gross, president of the Brady Campaign to Prevent Gun Violence, makes a passionate, personal appeal for something that more than 90 percent of Americans want: background...

Justin Baldoni wants to start a dialogue with men about redefining masculinity -- to figure out ways to be not just good men but good humans. In a warm, personal talk, he shares his effort to reconcile who he is with who the world tells him a man should be. And he has a challenge for men: "See if you can use the same qualities that you feel make...

With words like shards of glass, Chinaka Hodge cuts open 2016 and lets 12 months of violence, grief, fear, shame, courage and hope spill out in this original poem about a year none of us will soon forget.

Breast milk grows babies' bodies, fuels neurodevelopment, provides essential immunofactors and safeguards against famine and disease -- why, then, does science know more about tomatoes than mother's milk? Katie Hinde shares insights into this complex, life-giving substance and discusses the major gaps scientific research still needs to fill so w...

Shonda Rhimes, the titan behind Grey's Anatomy, Scandal and How to Get Away With Murder, is responsible for some 70 hours of television per season, and she loves to work. "When I am hard at work, when I am deep in it, there is no other feeling," she says. She has a name for this feeling: The hum. The hum is a drug, the hum is music, the hum is G...

We need women to work, and we need working women to have babies. So why is America one of the only countries in the world that offers no national paid leave to new working mothers? In this incisive talk, Jessica Shortall makes the impassioned case that the reality of new working motherhood in America is both hidden and horrible: millions of wome...

Sue Desmond-Hellmann is using precision public health -- an approach that incorporates big data, consumer monitoring, gene sequencing and other innovative tools -- to solve the world's most difficult medical problems. It's already helped cut HIV transmission from mothers to babies by nearly half in sub-Saharan Africa, and now it's being used to ...

How do you define "nature?" If we define it as that which is untouched by humans, then we won't have any left, says environmental writer Emma Marris. She urges us to consider a new definition of nature -- one that includes not only pristine wilderness but also the untended patches of plants growing in urban spaces -- and encourages us to bring o...

Creating genetically modified people is no longer a science fiction fantasy; it's a likely future scenario. Biologist Paul Knoepfler estimates that within fifteen years, scientists could use the gene editing technology CRISPR to make certain "upgrades" to human embryos -- from altering physical appearances to eliminating the risk of auto-immune ...

For the first time in history, the majority of American parents don't think their kids will be better off than they were. This shouldn't be a cause for alarm, says journalist Courtney E. Martin. Rather, it's an opportunity to define a new approach to work and family that emphasizes community and creativity. "The biggest danger is not failing to ...

Muscles and joints shift and jostle. The heart's pounding rhythm speeds up. Blood roars through arteries and veins. Over the course of a pregnancy, every organ in the body changes. Initiated by a range of hormones, these changes begin as soon as a pregnancy begins. Explore what we know— and don't know— about pregnancy's effects on the body and b...

Steven Pinker's book The Blank Slate argues that all humans are born with some innate traits. Here, Pinker talks about his thesis, and why some people found it incredibly upsetting.

Short videos -- 60 seconds or less, made and shared on apps like TikTok, Snapchat and Instagram -- are more than just a fun way to pass the time; they've transformed how we work, communicate and learn. Digital strategist Qiuqing Tai explores the explosive rise of bite-sized content and forecasts its promise as an economic and social force.

Artist Raghava KK demos his new children's book for iPad with a fun feature: when you shake it, the story -- and your perspective -- changes. In this charming short talk, he invites all of us to shake up our perspective a little bit.

What is it like to raise a child who's different from you in some fundamental way (like a prodigy, or a differently abled kid, or a criminal)? In this quietly moving talk, writer Andrew Solomon shares what he learned from talking to dozens of parents -- asking them: What's the line between unconditional love and unconditional acceptance?

A mother honeyguide has placed its chick into a bee-eater's nest— puncturing all the other eggs in the nest and leaving only its own hatching alive. Over the following weeks, the host parents devotedly care for the hatchling whose mother murdered their offspring. This is brood parasitism, a phenomenon which is especially well-known among birds. ...

"It is the artist's job to unearth stories that people try to bury with shovels of complacency and time," says poet and freedom fighter Mwende "FreeQuency" Katwiwa. Performing her poem "The Joys of Motherhood," Katwiwa explores the experience of Black mothers in America and discusses the impact of the Movement for Black Lives -- because, she say...

As kids, we all get advice from parents and teachers that seems strange, even confusing. This was crystallized one night for a young Clint Smith, who was playing with water guns in a dark parking lot with his white friends. In a heartfelt piece, the poet paints the scene of his father's furious and fearful response.

We're taught to try to live life without regret. But why? Using her own tattoo as an example, Kathryn Schulz makes a powerful and moving case for embracing our regrets.

Is it possible to run a company and reinvent it at the same time? For business strategist Knut Haanaes, the ability to innovate after becoming successful is the mark of a great organization. He shares insights on how to strike a balance between perfecting what we already know and exploring totally new ideas -- and lays out how to avoid two major...

"For all that's ever been said about climate change, we haven't heard nearly enough about the psychological impacts of living in a warming world," says science writer Britt Wray. In this quick talk, she explores how climate change is threatening our well-being -- mental, social and spiritual -- and offers a starting point for what we can do abou...

With his signature charm and searching insight, David Whyte meditates on the frontiers of the past, present and future, sharing two poems inspired by his niece's hike along El Camino de Santiago de Compostela in Spain.