Jay Walker is fascinated by intellectual property in all its forms. His firm, Walker Digital, created Priceline and many other businesses that reframe old problems with new IT. In his private life, he's a bibliophile and collector on an epic scale.
In 2004, Sal Khan, a hedge fund analyst, began making math tutorials for his cousins. Twelve years later, Khan Academy has more than 42 million registered users from 190 countries, with tutorials on subjects from basic math through economics, art history, computer science, health, medicine and more.
A living legend, Frank Gehry has forged his own language of architecture, creating astonishing buildings all over the world, such as the Guggenheim in Bilbao, the Walt Disney Concert Hall in LA, and Manhattan's new IAC building.
Bono, the lead singer of U2, uses his celebrity to fight for social justice worldwide: to end hunger, poverty and disease, especially in Africa. His nonprofit ONE raises awareness via media, policy and calls to action.