Finding and bringing closure

In a lyrical, unexpectedly funny talk about heavy topics such as frayed relationships and the death of a loved one, Elizabeth Lesser describes the healing process of putting aside pride and defensiveness to make way for soul-baring and truth-telling. "You don't have to wait for a life-or-death situation to clean up the relationships that matter to you," she says. "Be like a new kind of first responder ... the one to take the first courageous step toward the other."

After Sarah Gray's unborn son Thomas was diagnosed with anencephaly, a terminal condition, she decided to turn her family's tragedy into an extraordinary gift and donate his organs to scientific research. In this tribute to life and discovery, she shares her journey to find meaning in loss and spreads a message of hope for other grieving families.

To those who feel like they don't belong: there is beauty in being a misfit. Author Lidia Yuknavitch shares her own wayward journey in an intimate recollection of patchwork stories about loss, shame and the slow process of self-acceptance. "Even at the moment of your failure, you are beautiful," she says. "You don't know it yet, but you have the ability to reinvent yourself endlessly. That's your beauty."

When Amy Green's young son was diagnosed with a rare brain tumor, she made up a bedtime story for his siblings to teach them about cancer. What resulted was a video game, "That Dragon, Cancer," which takes players on a journey they can't win. In this beautiful talk about coping with loss, Green brings joy and play to tragedy. "We made a game that's hard to play," she says, "because the hardest moments of our lives change us more than any goal we could ever accomplish."