Disruption is usually unwelcome. It represents conflict, chaos, and potential danger. We discourage disruptive behavior in our homes and our societies, often favoring passivity and compliance. But disruption can be a positive – sometimes vital – catalyst for change. It can challenge old assumptions, ignite conversations, activate authorities and expose new possibilities. Disruption can shed a unique light on difficult issues, giving a fresh urgency and perspective to the challenges of our global community. To solve the most intractable challenges in health and development, we need positive disruption. It is the path to true progress.