Ex Nihilo means choosing to construct, deciding to bring into being; it has a binary aspect. On one side is emptiness, non-existence, the void - Nihilo. On the other is creation, it comes out of nothingness and into being. Ex Nihilo is where paradigm shifts happen. The old order of things gives way to novel ideas, disruptive invention, and brand new discoveries. Quantum leaps of progress and improvement.
The necessary conditions don't come along every day but when they do, you'd better get ready. Everything will be challenged.