Relevant notes and citations provided to TED by Kevin Stone.
"Cancer Prevalence: How Many People Have Cancer?," American Cancer Society, October 25, 2013
An estimated 13 million living people in the US have been diagnosed with cancer at one point in their life.
Reva Lawrence et al., "Estimates of the prevalence of arthritis and other rheumatic conditions in the United States, Part II," Arthritis and Rheumatism, January 2008
In 2008, an estimated 27 million adults in the US had been diagnosed with osteoarthritis, up from 21 million people in 1995. That figure is likely to increase again.
Louise Murphy et al., "Lifetime risk of symptomatic knee osteoarthritis," Arthritis and Rheumatism, September 2008
Nearly one in two people may develop symptomatic knee osteoarthritis by the age of 85.
Kevin Stone et al., "Meniscus allograft survival in patients with moderate to severe unicompartmental arthritis: A 2- to 7-year follow-up," Arthroscopy, May 2006
Meniscus allografts can survive in a joint with arthrosis, challenging the contraindications of age and arthrosis severity. These results compare favorably with those in previous reports of meniscus allograft survival in patients without arthrosis.
Kevin Stone et al., "Articular cartilage paste grafting to full-thickness articular cartilage knee joint lesions: A 2- to 12-year follow-up," Arthroscopy, May 2006
Paste grafting is a low-cost, one-stage arthroscopic treatment for patients with Outerbridge classification grade IV arthritic chondral lesions. The procedure offers excellent, long-lasting pain relief, restored functioning and possibility of tissue regeneration for patients with painful chondral lesions in both arthritic and traumatically injured knees.
Kevin Stone et al., "Meniscal regeneration with copolymeric collagen scaffolds," American Journal of Sports Medicine, March/April 1992
This study suggests that effective meniscal regeneration can be supported by an implanted collagen-based scaffold designed to support cellular ingrowth.
Kevin Stone et al., "Porcine cartilage transplants in the cynomolgus monkey," Transplantation, June 27, 1998
Treatment of cartilage xenografts with alpha-galactosidase successfully removes alpha-gal epitopes from porcine cartilage. Transplantation of the treated cartilage results in the production of only anti-porcine cartilage-specific antibodies and a reduced inflammatory response consisting primarily of macrophages infiltrating into the cartilage.
Kevin Stone et al., Anterior cruciate ligament reconstruction with a porcine xenograft: A serologic, histologic, and biomechanical study in primates, Arthroscopy, April 2007
Rhesus allograft and treated porcine grafts presented with similar healing profiles in a long-term evaluation of ACL reconstruction.