Nancy Maguire Posted almost 3 years ago How can creativity and chronic depression coexist? Your "muse" needs to be pampered and respected, the vacillation between creativity and down time as you describe it is in my mind the nature of creativity - which is to often pathologized. Not to say that you have not been depressed. A muse is a sensitive being who wants to come and visit you - yes sometimes late at night - but then will exhaust you and be gone, until she arrives again. Creativity is a gift and a challenge.