david woynarowski

CEO, drdavesbest
Reading, PA, United States

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david woynarowski
Posted over 4 years ago
What is the best way to leverage telomere science to increase longevity, what will have the greatest impact on telomeres, diet, supplements?
Hi Robert I encourage you to read our book the Immortality Edge as all of that is in there in prescriptive fashion. In addition you might want to scan my articles on healthiertalk.com because all of these questions have been answered there extensively. They were simply not part of this particular discussion until now. I am not a huge fan or resveratrol as an anti-aging compound in humans at least not just yet. The effects on cancer are of course in genetically modified human cell lines and the human being studies show resveratrol works via adipokines mechanism not SIR mechanisms. That said I think of it as a good anti-oxidant that is still hunting for a mechanism other mechanisms in people to justify its reputation. That of course does not preclude additional discovery but at this point I usually have to roll my eyes when people say they are taking resveratrol or blueberry extract (pterostilbene) for longevity. You’d be far better off balancing your Omega 6 to omega 3 ratios with whatever dose of fish oil is needed for you to do that! There is a clear cut distinction between “extending life” by improving health and approaching our genetically pre programmed limit and having health and reversing aging while extending life to a new limit. In most cases the authors of various articles are really talking about the former not the latter. The former may indeed have some contribution from resveratrol or like polyphenols, the latter will as we have seen in mice and human populations require extension of the telomeres not just their preservation. As to cancer there are several mechanisms that have to be bypassed and immunosenescence is part of that problem. Cancer is a disease of short telomeres not long unless you figure in the rare ALT mechanisms which comes at the expense of recombination. Cancer also “over expresses” telomerase by as many means as you can think of all at once. Adding TA-65 to pre malignant cells does not increase cancer transformation. Adding TA-65 to cancer prone mice does not increase cancer transformation. And in the human study TA-65 did not lead to any increases in cancer transformation. Cancer makes telomerase not the other way around. Finally turning on telomerase in the aged mouse model REVERSED aging not just stopping it. This study was actually done more than once although the most recent one got all the airplay. Mouse studies where human skin was grafted on to the mice and then telomerase was turned on returned the human skin to a younger phenotype with young genetic expression. None of the other interventions will do that! Again all of this is the topic of the Immortality Edge! Best Dr Dave
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david woynarowski
Posted over 4 years ago
What is the best way to leverage telomere science to increase longevity, what will have the greatest impact on telomeres, diet, supplements?
Hello all glad I saw this post as I am an author of the Immortality Edge. This is a really good question and reminds me of the very same question I asked at an anti-aging conference 12 years ago. At that time I was asking about supplements diet and hormone replacement since that is pretty much all that was studied. The answer was “diet”. But that was then and this is now. The answer has not really changed all that much but we need say nutrition and include supplements in that discussion. Telomere based interventions are absolutely worthwhile since pretty much everything is point that way as the key to not only slowing maybe even stopping aging but having great health in the process. We can divide them into 2 separate arms-those that slow down telomere loss and those that add telomere length. Those that slow down telomere loss include proper diet sleep exercise and meditation and quite a few supplements. Diet wise I recommend a Paleolithic diet since preliminary data suggest it may slow down telomere loss and it fits our genetic evolutionary pattern. If you were to ask me what was the easiest thing to do I would have to say supplements and with all the data coming out of supplement intervention there is more and more cause to say if you do nothing else…The standouts in the supplement category are fish oil Carnosine Co Q 10 Vitamin D3 and green tea presumably including the extracts. None have been shown to increase telomere length however. So simply put they may help ou get closer to our maximum predetermined life span and in at least several of the above cases can improve your health or prevent future illness. As far as Adding length to your telomeres only one supplement called TA-65 does that in safe fashion in humans. There is nothing else that does this including prescription drugs and all of the above life style modifications. There is one human study on TA-65. They did not control for diet or supplement use (although some people did use other supplements). In that study TA-65 seemed to work where it was needed most in just about everyone who took it. It is considered very expensive by many people ranging anywhere from $6 to $25 a day depending on the dose. I am a bit biased when it comes to the cost because I feel my life and health have no set price tag. In addition I had been waiting for something like this for years when it finally came out a while back. Higher doses seem to be most effective although there is some effect at all the recommended doses. It seems to work pretty much no matter how bad you treat yourself although I am certain you can “make its job much easier and get far better results even, if you do ALL of the things. The most dramatic effects of exercise have been shown in elite long term highly conditioned middle distance runners who had been running for 20 years on average. Their telomere length was actually close to that of a 25 year old. That is obviously a pretty select group but other studies have shown that vigorous exercise for periods of even 2 years yield benefits in telomere length and functional measurement so aging like lung capacity. For most short high intensity “interval type training” yields a lot of functional benefits and minimal oxidative stress so this is what most people need. So what should you do? Everything you can. The more good things you do for your telomeres the better off you’ll be. If you can afford it the most promising and dramatic results are with TA-65. Even if you do everything else right, you will not add length to your telomeres the study is out there about TA-65 in people, free on the internet in the Journal of Rejuvenation Research but I can share a few personal notes. I do a lot of interval training obviously but I also train for ultra marathons from time to time. TA-65 made me a lot faster. As a matter of fact I was able to take a full minute off my 1 mile interval times doing nothing else 3 weeks after I started it. I also recover faster from the long runs when I do them. I haven’t been sick since I started taking it even though as a doctor I am around a lot of sick people. The mental focus and sexual energy are well… astounding. I also have lengthened my telomeres to equate to about 5 years younger. I am on the highest dose and have been on that dose now for about 2 years. The study I mentioned above show that TA-65 works in a dose dependent fashion. The problem I have found is that the lower dose does work on telomeres but people do not feel the other stuff I mentioned above until they get to the higher doses. At least not right away. For most knowing their “biologic fuses” aren’t burning down is good enough. There are a good many other things you can and should do whether or not you can afford TA-65. Our book The Immortality Edge is obviously my favorite reference as well for all of the above. It’s pretty easy to read but thorough. It’s loaded with prescriptive advice that is easy to follow. In fact it’s pretty much the ONLY reference of its kind.