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Anuraag Reddy

AIESEC India

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Why evolution could never solve aging?

Maybe aging is an essential mechanism to clear out the old and make way for the new like cells within a body?

Maybe every form of life is already close to the upper limit of life expectancy?

Maybe aging is in the nature of carbon based life and metabolism?

Maybe we genetically sacrifice our longevity to survive the stresses of competition.

Emerging Questions:
Is it that our metabolic processes are over-compensated for dominance in their sexual prime which prove detrimental for longevity?

Is it that genes leading to different lifespans are mixed indefinitely in nature that it was never possible to select for it?

Isn't an organism with a longer span of mating at an advantage?

My hypothesis:
In the absence of change in ones environment, or competitive stresses an organism would eventually adapt itself to survive longer.

If every organism is a product of evolution then there must of course be underlying mechanisms within itself to aid such an adaptive process.

Under the influence of adaptive pressure, it would encourage mutation or variations in order create successful variations and also increase the number of life-cycles and so reducing the lifespan.

Under the influence of competitive stress, the dominance would lead to reproductive success and not the span of mating during ones lifespan.

In the absence of change in ones environment leading to adaptive pressure, or competitive stresses from rivals to prove dominance. Species would evolve longer lifespans.

Just a Theory though! But it would predict that

Lifespans of living fossils which have undergone little change in time should be greater than their relatives which have recently evolved.

Life having evolved on geographically isolated places far from intense competitive pressures should have greater lifespans.

Living things higher up in the food-chain or with few natural enemies should have greater lifespans.

Life span in pair bonding species should be higher than tournament species.

Topics: aging evolution
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  • Dec 16 2011: if there is no change

    anf that includes "aging" there would be no "evolution"
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    Dec 16 2011: That was quite confusing...not sure how to respond or in which order, so I will just share what I know:

    Bacteria basically life forever, since they only copy themselves. During that process some errors can sneak in which might make them more or less efficient at surviving or have no immediate effect at all. That leads to a slow evolution, which is ok as long as the population is as huge as bacteria populations are. Survival is pretty much luck since these organisms are so simple and therefore vulnerable to environmental conditions. Again their number helps the species to survive.

    Sexual reproduction is another story. The possibility for change in the genome by mixing two of them instead of copying one is much higher, which leads to faster adaption and therefore bigger populations. Also the complexity of the organisms increases drastically. With higher complexity comes higher vulnerability to errors during the cloning process(a glass of water can destroy a computer, but not an abakus to use a simple allegory). these errors accumulate in multicellular organisms until they cease to function, which is called "aging". The errors in the process can happen randomly which is rare or be induced by environmental factors such as chemicals or radiaton.
    In short: We age, because we are too complex to function longer than we do.

    And to adress the longevity:
    Every individual of a species has a lifespan that is high enough to reproduce and in some cases make sure the offspring survive. Anything else would be a waste of resources that would harm the population. This lifespan is determined by the environmental conditions and the sice of the organism. Big organisms that live long evolve in stable environments and have slow reproduction rates. Smaller organisms that live shorter evolve in less stable environments and have to reproduce faster.
    In short: You live as long as you have to, but not longer, because nature can't afford to care about individuals
  • Dec 9 2011: Your hypothesis does not seem to answer your own question. It maybe more appropriate to ask- Why do some species have longer life spans than others? If you are in fact trying to answer this question then I believe you have provided a hypothesis that confuses 2 elementary principles that are essential in understanding and explaining evolution and natural selection ie. Individuals adapt. Populations evolve.
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    Dec 9 2011: Evolution HAS solved aging.

    The modern shark has been around for about 100 million years. If that isn't a long life span, then I don't know what is.

    Evolution doesn't work on an individual scale. It works across entire species, and can solve the aging problem when you look at it from the perspective of a species, and not as an individual. I will die, but my children will live on. Presumably, they will have children, and those children will have children, and my genetics will continue to live on forever.
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    Dec 8 2011: The purpose of evolution is not to prolong life, it is to ensure a specie's ability to procreate. Evolution never solved aging because that isn't evolution's problem to solve.
  • Dec 6 2011: If we're approaching this from a human genetic standpoint then you have to consider that genes won't propagate, quickly, to enact change when there isn't a selective pressure. Almost all human genetic changes are going to be of rates unoticeable to us, barely perceptibly above the norm, because of the cultural influences upon sexual health and family life.

    As for aging you have to ask yourself is there really a significance currently to a longer period of sexual activity to your offspring surviving? How is that limited by things like the menopause and old men losing virilence? And does a longer period of sexual activity actually have any real statistically relavent effect upon the average number of children a person has.

    I very much doubt a longer lifespan actually will contribute to the number of children produced in a western community with good sexual health education. A brief observation is that women are making choices about when to have children increasingly closer to the onset of menopause so they can accomplish a greater number of goals in their youth. If you expand the aging process in a means that produces a greater period of youth I can only conclude that women will continue to choose to have children closer to when the threat of not being able to ever have children compels a desire to do so.
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      Dec 8 2011: This is another socioeconomic selection trend that is well observed, definitely interesting and something new to this conversation.

      There is also a tendency for son's of rich, successful older men having sons who have better chances of mating themselves.

      Both should definitely be leading to longer lives at least among st humans.
  • Dec 6 2011: I believe that aging must be the best possible outcome for humans.
    Without aging we'd have a harsh choice to make:
    No new people
    Or mandated 'exit strategy' for current people.
    Either one is unfavorable vs. what we have.
  • Dec 6 2011: Because it didn't need to.
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    Dec 6 2011: I believe Aging is definitely a problem, and with all due respect and humility, I believe it is a design flaw. Evolution has not kept up with Entropy. Humanity now has the chance to manage Aging. I believe that if Humanity got along with itself, we could all live a joyful, loving 500 years or more. The Earth could safely hold 20 billion people, and we could also be living on other planets.
  • Steve G

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    Dec 6 2011: Being more a philosopher than a scientist, I can best address why aging isn't a "problem". Perhaps you can draw scientific conclusions. 1. Other people are environmental factors, and in today's world, the ideas held by people also become environmental factors which in a real way effect biological evolution. If people were not to age and die, that environment would begin to homogenize (peoples ideas don't change with any predictability or guarantee), and with less environmental variety, there would be less to adapt TO. 2. The gene pool stays the same longer - similar problem: the opportunities for different types of mutations becomes limited.
    Some of your hypotheses seem to favor this kind of homogeneity - a problem is that it is a little self-contradictory to speak of evolution in an environment in which change becomes a non-factor. If such "favorable" conditions did occur, evolution would almost certainly stop too - thus nothing new, including new lifespans. (It is important to consider that while adaptation and mutation certainly will always be the condition of living things, the term "evolution" is almost always used to describe, only with 20/20 hindsight, such a mutation that we qualify as "good". Also, barring such ephemera as "the human ego", where is the evidence that living longer is an improvement? )
    And importantly, if Evolution is your ruler, then measuring by that ruler indicates that the proper lifespan for each living entity = well.... it's current lifespan.)
  • Dec 6 2011: Being too improbable to ever occur is a bit of an odd thing to say, when the probability of us being here is almost impossible given another chance to start again. I think maybe "age" or "life cycle" or whatever, is relative to the size and time frame of the entity. Say, the universe is infinitely large, and for all we know, will go on for ever. Galaxies last for hundreds of billions of years (or so we think). Stars for many billions, etc. So maybe, because we move at such a speed in comparison to these larger entities, we live much shorter existences, like dogs or cats compared to us, or a cell.
  • Dylan F

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    Dec 6 2011: A beautiful principle of evolution is that its designs only have to work well enough - well enough for the genes of an individual to propagate to successive generations. Perhaps the sheer evolutionary costliness of immortality for a mammal has proven too much and a higher metabolism was favored as a more engaged nervous system could live long enough to sufficiently reproduce.

    Although the mechanisms responsible for aging are not exactly known, it is clear that it's a complex matter involving many different biochemical factors. To overcome such a feat by natural selection may simply be too improbable to ever occur or it may need not ever occur because of easier solutions (higher metabolism = shorter life, but more strength, speed, intelligence for more reproduction = more genes in the gene pool to favor shorter life).

    But, on the other hand, evolution has stumbled upon a species capable of redesigning its very own nature with the potential of reaching conscious immortality. So maybe the question is "When will evolution solve the problem of aging?"
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      Dec 8 2011: You seem to be in favor of the Antagonistic pleiotropy theory: Late-acting deleterious genes may even be favored by selection and be actively accumulated in populations if they have any beneficial effects early in life.

      A likely possibility and well arrived at. :)
  • Dec 5 2011: Denomyar01,To be honest, I must say that, Yes it did feel good to bring tony in line. I was simply reminding him of the fact that this is not a theological argument but rather a SCIENTIFIC discussion.

    And about the lines that we draw for the categorization of various things like your example of life, there is a line, just that it isn't a distinct line but a fuzzy line. In the words of Jane Goodall, "it's a very wuzzy line, and its getting wuzzier all the time". Ofcourse she was talking about the divide between humans and the rest of the animal kingdom. Yes classification is difficult and we have things that fall on either side and some that dont find a side to fall on, a typical example being the one stated by Tony in his first post, the Virus, it becomes inanimate when in harsh conditions and animate again when favourable conditions prevail.

    To address the last issue you brought up, The religious being courageous enough...hmm.. hiding from simple facts of life and death and crediting an imaginary being for everything good that happens, then depending on the said being to give you presents if you're good... sounds very courageous indeed. I was religious, untill I started THINKING for MYSELF. never turned back ever since, because I get real answers from science and not answers like "That's just how it is" or "god did it".

    Please look into the actual working of the Big Bang theory and quantum physics before you assert that real SCIENTIFIC theories are just made up by a bunch of people as fictional writing. I would suggest a reading of Hawking's 'A brief history of time'. Brilliantly written for the lay man to understand. You could watch his documentaries too if required (which I honestly feel might be required), and if you're even going to venture say that he's not qualified enough to talk on the topic, Im sorry my friend, I have nothing else to say to you.
    Have a good day.
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    Dec 5 2011: For those curious about increased longevity mutations, google Cynthia Kenyon (a TED speaker) and her daf mutations. (This concerns C. elegans, a tiny roundworm, about which more is known than any other animal... I used to do electron microscopy on these for Bob Horvitz, Nobel Prize laureate from MIT) Normal worms have a number of "housekeeping genes" (antioxidants, DNA repair enzymes, etc.) that are usually turned off. In a mutant where these genes are turned on, the worm lives twice the normal period! A small number of insulin-like signal systems seem to control these pathways, and it was found that sugar shortens the worm's life, but only if they have intact insulin receptors. People like Kenyon will probably discover a drug, that, combined with an optimal diet, will slow the aging process! What works in the worm, thanks to evolution, tends to work in people. I think having a small population of long-lived people, who can "bring history alive", and tell future generations what the world was like when there were coral reefs, etc., would be a good thing.
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    Dec 4 2011: i think the reason evolution never overtook age is because without the position of death and decay our bodies would never evolve. the more a organism decays the more it changes/mutates and potentially "evolves" to survive longer within its environmental stresses. of course this pattern only counts within repetition of conspetion of offspring.
  • Dec 4 2011: Honestly Tony, When I saw you comment in a discussion of such high stature,(I hold TED to be of very high stature). I did not expect you to fall so low to the level of trying character assassination. I honestly thought you would understand that bringing theology into a scientific argument is baseless and irresponsible, and yet even while trying to insult me over here you bring it up over here. Now I truly am ashamed to be a part of a conversation where such and ignorant and childish attitude can be entertained. I'd like to wish you all the best in your endeavors to try and convert people. I dont insult people till I know them, so have a great day. This will be the last time I waste my time on you. Cheers
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    Dec 2 2011: These are some sensible theories widely accepted by the Scientific Community that I stumbled upon while browsing. Although that is what this conversation arrived at independently, thanks to all the incredible contributions. Cheers! :)

    Mutation accumulation theory: From the evolutionary perspective, aging is an inevitable result of the declining force of natural selection with age. For example, a mutant gene that kills young children will be strongly selected against (will not be passed to the next generation) while a lethal mutation with effects confined to people over the age of 80 will experience no selection because people with this mutation will have already passed it to their offspring by that age. Over successive generations, late-acting deleterious mutations will accumulate, leading to an increase in mortality rates late in life.

    Antagonistic pleiotropy theory: Late-acting deleterious genes may even be favored by selection and be actively accumulated in populations if they have any beneficial effects early in life.

    ‎"If you can't explain it simply, you don't understand it well enough." ~ Einstien

    A Good Read:
    http://longevity-science.org/Evolution.htm
  • Dec 2 2011: Hi and how are ya? Evolution is what it is. Humans age. Food chains, are a fact of life. ( crap, another wrinkle) :)
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    Dec 2 2011: Evolution's aim is not to prolong the lives of the living, but to facilitate reproduction and improve such beings. In order to have a world in which species are constantly progressing and moving toward better versions of themselves, the death/life cycle is a necessity. In fact, the faster we are replaced by newer beings, the faster evolution and adaptation can progress. The very thought of creatures that have yet to be improved upon living long lives goes against evolution. Evolution would only produce immortality/anti-aging if it had created a perfect being that could no longer be improved upon. But, seeing as that will never happen considering the constantly changing universe, immortality never will either.
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    Dec 2 2011: Who said that immortality is the purpose of life. That is just something humanity came up with and we have been around for a couple hundred thousand years. Why should the process of evolution have a goal.
  • Dec 2 2011: Well the human species is genetically "programmed" to live to 120 years. But due to the tremendous amount of stress in our world, and due to killing off all the other killer which allowed cancer to flourish, the average life expectancy of men is only 73.7. That's around 58% of what we can live to ideally.
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    Dec 2 2011: I would say that evolution "solves" problems that it has access to. In other words, what would be the selectable environment for longer life? Success in evolution comes from variability and selection. If organisms didn't die, then there would be no evolution at all. Some organisms have success by having very short lifespans, while reproducing "like flies," other organisms are a tad slower at reproducing, but are able to survive longer and gather the strength to help the offspring survive, et cetera, et cetera.

    Evolution is a natural phenomenon, not an intelligent agent.
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    Dec 1 2011: Not all organisms age.

    Dieing is a selection step within the process of evolution. If you would implement any of the evolutionary algorithms you would understand it better. http://en.wikipedia.org/wiki/Evolutionary_algorithm

    Human race managed to escape evolutionary pressure by not of adapting, instead we are changing our environment (irrigation, shelter, heating, clothing, sanitation etc.).

    That being said, I still wish I would not have to die someday...
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    Dec 1 2011: might have something to do with order and disorder, after all we are matter essentially.
  • Dec 1 2011: Species are locked into a predator-prey arms race, so the survival strategy would be genetic variation within the species, and strategic alliances with other species. Living for a long time would be like standing still in the middle of a battlefield. In our species we are no longer fully part of this predator-prey arms race, so we see our lifespan increase. Those living to 100+ can be sequenced and their genetic information can be used to increase the lifespan of our species.
  • Nov 30 2011: I do not think it would be in evolution's interest to solve aging. Aging and death are necessary for evolution. If the weak ones do not die, then there is no evolution.There would still be a couple accidental deaths and competition etc. But the number of deaths would be less. This could increase crowding and therefore competition and just balance out the death toll.

    I do agree that we would probably live longer if our environment was unchanging though. We would just evolve to an optimum stage and remain that way. But given that our environment is ever changing and that we are constantly confronted with new viruses, competition etc, it is only natural that there would be some regular 'pruning' going on to keep the amount of genes circulating abundant. If we were all the same, then mass deaths would be even more frequent.

    I do wonder how species that live longer cope though.
  • Nov 30 2011: I am going to say something that. Does not fit at all! But maybe because we should learn to participate our surroundings more, before we get the privelege to stop aging. Understand total bliss, nirvana.