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When is it is wrong to take away the autonomy of an organism?
I was watching several talks on bio-engineering videos in a playlist, and the last video was a talk about ethics. I watched the whole video, and during most of the examples shown, I did not have a problem with the experiments, until he got to the insects hooked up to computer chips. I was absolutely fine with glowing kittens and rats with human ears sticking out of them, but taking away the autonomy of another living thing felt wrong to me. A simple roach, controlled by way of a chip hooked up to its brain elicited a response of wrongness in me that I did not fully understand. After all, it is just a roach, it wont live long anyway; yet this was not right to me. After considering it for a few minutes, I came to the conclusion that, if it is born to be a rat, it should be a rat. If you can breed it, or change it while it is still developing in the womb to follow your commands, then that is fine.
This led to another question. Isn't putting a bird in a cage controlling the bird? Isn't it just as bad? It isn't. When you put a bird in a cage, you are restricting its range of decisions, not determining them. The bird can choose to squawk or sing, but in the end it is the birds choice.
This question can be put in many different scenarios and circumstances, but what i am looking for is a simple, basic rule for when it is wrong or right.