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Can you make up for the lack of sleep?

First part of this question is quite obvious:
- with naps or sleeping in on the weekends, can I make up some of the sleep I lack at night since most of us have those dreadful 9-5 workdays?

second part (which is harder) is if I realize I have been sleep deprived my whole life (teenage years, and early twenties) (but TONS during college years)
is it possible to make up for those damages later on or has it already set in and is going to permanently effect me?

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